Comparison of Transumbilical Single‑Port and Multi‑Port Laparoscopic Myomectomy in Patients with Uterine Fibroids: Effects on Stress Response, Immune Function, and Incision Cosmetic Outcomes.
J Invest SurgJun 15, 2026 (epub)
Xila Wang, Chunjie Ye, Yuanxia Zou et al.
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In 30 seconds
This randomized controlled trial compared transumbilical single-port laparoscopic myomectomy (SPLM) and multi-port laparoscopic myomectomy (MPLM) in 146 patients with uterine fibroids. The SPLM group demonstrated reduced oxidative stress and improved immune function, with significant differences in stress markers at 3 days postoperatively. The SPLM group had shorter hospitalization despite longer operative times.
Key findings
- SPLM resulted in shorter postoperative exhaustion and hospitalization compared to MPLM (P < 0.05).
- At 3 days postoperatively, SPLM showed higher SOD and CD3+ levels and lower MDA and ROS levels than MPLM (P < 0.05).
- SPLM had higher cosmetic scores and lower BIS scores compared to MPLM (P < 0.05).
- Complication rates, menstrual recovery, and recurrence were similar between both groups (P > 0.05).
Why it matters
Understanding the differences in outcomes between SPLM and MPLM can guide surgical decisions for patients with uterine fibroids, particularly regarding recovery and cosmetic results.