Comparative efficacy of oral and long-acting injectable paliperidone on social functioning in schizophrenia: A systematic review and meta-analysis.
Schizophr ResJun 15, 2026 (epub)
Clinical ResearchPsychiatry
Yue Huang, Jiarong Zhang, Jie Ling et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of oral and long-acting injectable paliperidone on social functioning in schizophrenia, analyzing data from 20 RCTs and 38 single-arm trials. The findings indicated that paliperidone significantly improved Personal and Social Performance (PSP) scores compared to placebo, with a pooled mean difference of 2.51 (95% CI: 0.23 to 4.80).
Key findings
- Paliperidone improved PSP scores versus placebo with a pooled mean difference of 2.51.
- Single-arm trials showed a mean PSP increase of 9.46 points.
- Both paliperidone ER and LAI formulations were superior to placebo, with mean differences of 7.25 and 4.54, respectively.
- Improvements were most notable in patients with baseline PSP scores of 31-50.
Why it matters
Understanding the comparative efficacy of paliperidone formulations on social functioning can guide clinicians in treatment decisions for schizophrenia, emphasizing the importance of individualizing treatment based on patient needs and circumstances.