Network meta-analysis of randomized controlled trials evaluating long-term outcomes of interventional approaches for great saphenous vein insufficiency.
Fan Maitri Aldian, Yan Efrata Sembiring, Visuddho Visuddho et al.
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In 30 seconds
This network meta-analysis evaluated long-term outcomes of interventions for great saphenous vein (GSV) insufficiency in 7913 cases from 33 randomized controlled trials. High ligation and stripping (HL&S) demonstrated significantly higher long-term freedom from failure compared to cyanoacrylate closure, endovenous laser ablation, and radiofrequency ablation, with hazard ratios ranging from 1.98 to 2.64 (P < .001).
Key findings
- HL&S had a higher long-term freedom from failure compared to cyanoacrylate closure (HR, 1.98; P < .001).
- Electrocoagulation showed the lowest Venous Clinical Severity Score at 6 months (mean difference, -0.59; P = .03).
- Minimally invasive interventions allowed a faster return to normal activities compared to HL&S (P < .001).
- HL&S had a higher proportion of ecchymosis (76.37%) and infection (2.35%) compared to ablation procedures.
Why it matters
Understanding the long-term efficacy and safety of various interventions for GSV insufficiency is crucial for optimizing treatment strategies and improving patient outcomes. This analysis provides valuable insights for clinicians in making informed decisions.