Pediatric Castleman Disease Manifesting as a Lacrimal Gland Tumor.

Ophthalmic Plast Reconstr SurgJun 16, 2026 (epub)
Case ReportOphthalmologyPediatricsPathology (Anatomic & Clinical)Radiology (Diagnostic)

Tatiana R Rosenblatt, Jacob R Bledsoe, Caroline D Robson et al.

✦ AI-curated · Sources linked

Case in brief

A 15-year-old presented with progressive left eye bulging and intermittent periorbital pain. Imaging showed a well-defined, homogeneous, enhancing mass in the left lacrimal gland, with decreased diffusivity, smooth bone remodeling, and anteromedial displacement of the globe; no other systemic findings were reported. The lesion was completely excised, and histopathology showed hyaline vascular-type Castleman disease.

What made this case unusual

The report describes an isolated lacrimal gland lesion in a pediatric patient, an exceptionally uncommon orbital presentation of Castleman disease.

Diagnostic / clinical pearl

Castleman disease can present as a well-circumscribed, homogeneous lacrimal gland mass with decreased diffusivity and smooth bone remodeling; include it among the differential diagnoses for this imaging pattern.

Source

PubMed · PMID 42301293

Published in Ophthalmic Plast Reconstr Surg. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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