Genome-wide association study of creatinine clearance identifies new loci for kidney function.
Anna D Argoty-Pantoja, Peter J van der Most, Zoha Kamali et al.
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In 30 seconds
This meta-analysis of genome-wide association studies examined creatinine clearance (CrCl) in 58,976 individuals of European ancestry. The study identified 16 independent loci associated with CrCl, including two novel SNPs, rs146465192 and rs117014836, with P-values of 3.38 × 10 -9 and 5.42 × 10 -9, respectively. Additionally, two female-specific loci were identified.
Key findings
- Identified 16 independent loci associated with creatinine clearance (CrCl).
- Discovered two novel SNPs: rs146465192 (P = 3.38 × 10 -9) and rs117014836 (P = 5.42 × 10 -9).
- Two female-specific loci were associated with kidney function: rs8002366 and rs12908437.
- Both novel SNPs were also significantly associated with eGFRcrea in the Lifelines study.
Why it matters
Understanding the genetic basis of kidney function can enhance the identification of individuals at risk for chronic kidney disease. This study highlights the importance of using creatinine clearance as a measure independent of muscle mass, potentially leading to better risk stratification and management.