Effect of partial replacement of animal protein with plant protein on glycemic control in type 2 diabetes: Rationale, design, and protocol of a randomized clinical trial.
Clin Nutr ESPENJun 16, 2026 (epub)
Poliana E Correia, Paula P Teixeira, Bárbara B Martins et al.
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In 30 seconds
This randomized clinical trial investigates the impact of a plant-based diet with partial animal protein replacement on glycemic control in adults with type 2 diabetes and overweight/obesity. Participants are assigned to either a plant-based diet or a standard healthy diet, with the primary outcome being the difference in glycated hemoglobin (HbA1c) at 24 weeks. A total of 146 participants will be enrolled.
Key findings
- The primary outcome is the difference in glycated hemoglobin (HbA1c) at 24 weeks.
- Participants will receive individualized energy prescriptions targeting a 5% weight loss.
- The control diet consists of 15% energy from animal protein and 5% from plant protein.
Why it matters
Understanding the effects of flexible plant-based diets on glycemic control can inform dietary recommendations for managing type 2 diabetes, potentially improving patient outcomes and adherence to dietary interventions.