Treatment Strategies and Outcomes for Single-Site Recurrent Pancreatic Ductal Adenocarcinoma After Curative-Intent Surgery: Local Therapies are Associated with Longer Survival in Selected Cases: A Systematic Review and Meta-analysis.
Aya Maekawa, Giampaolo Perri, Danhui Heo et al.
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In 30 seconds
This systematic review and meta-analysis examined treatment strategies for recurrent pancreatic ductal adenocarcinoma (PDAC) after curative surgery, focusing on patients with liver-only, lung-only, or locoregional recurrence. The analysis revealed that local therapies, particularly surgical resection, were associated with significantly longer overall survival compared to conventional management, with a hazard ratio of 0.26 for liver-only recurrence.
Key findings
- Local therapy for liver-only recurrence was associated with longer overall survival than chemotherapy alone (HR 0.26).
- Surgical resection for lung-only recurrence showed longer survival compared to conventional management (HR 0.35).
- Resection for locoregional recurrence was linked to longer survival (HR 0.52).
Why it matters
Understanding the impact of treatment strategies on survival outcomes for recurrent PDAC is crucial for optimizing patient management. This study highlights the potential benefits of local therapies, which may guide clinicians in making informed decisions for recurrence treatment.