A Multicentre Phase II Study of Trifluridine/Tipiracil in Recurrent/Metastatic Platinum-Resistant Nasopharyngeal Carcinomas.

Clin Cancer ResSep 1, 2026
Clinical ResearchOncology (Medical)Open access

Jia Li Low, Wan Qin Chong, Edwin Pun Hui et al.

✦ AI-curated · Sources linked

In 30 seconds

This multicenter Phase II study evaluated the efficacy and safety of trifluridine/tipiracil (FTD/TPI) in 35 patients with recurrent/metastatic platinum-resistant nasopharyngeal carcinoma. The disease control rate at 12 weeks was 57.1%, with a median overall survival of 13.1 months, indicating promising antitumor activity and a manageable safety profile.

Key findings

  • The disease control rate at 12 weeks was 57.1% (95% CI, 39.4%-73.7%).
  • The overall response rate was 22.9% (95% CI, 10.4-40.1).
  • The median progression-free survival was 6.5 months.
  • Grade 3 to 4 neutropenia was significantly associated with improved overall response rate (P < 0.001).

Why it matters

The study highlights a potential new oral treatment option for patients with limited therapeutic choices in recurrent/metastatic nasopharyngeal carcinoma, demonstrating both efficacy and a manageable safety profile.

Source

PubMed · PMID 42307653Free full text on PubMed Central

Published in Clin Cancer Res. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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