The role of pro-inflammatory cytokine gene polymorphisms in major depressive disorder: a systematic review.
Pharmacogenet GenomicsJul 28, 2026 (epub)
Clinical ResearchPsychiatry
Yuvapriya Kalidasan, Vettriselvi Venkatesan, Suvarna Jyothi Kantipudi et al.
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In 30 seconds
This systematic review evaluated the association between pro-inflammatory cytokine gene polymorphisms, specifically TNF-α and IL-1β, and major depressive disorder (MDD) in adult populations. Nine studies were included, revealing significant associations between these polymorphisms and increased susceptibility to MDD, suicide risk, and treatment response, although results varied across ethnic groups.
Key findings
- Significant associations were found between TNF-α and IL-1β polymorphisms and increased susceptibility to MDD.
- Polymorphisms were linked to suicide risk and severity of depressive symptoms.
- Variability in findings was noted across different ethnic groups and study populations.
Why it matters
Understanding the genetic factors associated with MDD can help clinicians identify at-risk patients and tailor treatment strategies. The role of inflammatory cytokines in MDD highlights the potential for novel therapeutic targets.