Preliminary efficacy of a self-guided mobile intervention for reducing stress in depression: A randomized controlled crossover trial.

J Affect DisordJun 17, 2026 (epub)
Clinical ResearchPsychiatry

Junhyung Kim, Seung-Hoon Lee, Cheolmin Shin et al.

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In 30 seconds

This multicenter, randomized controlled crossover trial evaluated the efficacy of a self-guided mobile intervention, inMind, for reducing stress in individuals with mild-to-moderate major depressive disorder (MDD) undergoing pharmacological treatment. The study found that inMind was associated with a reduction in the DASS-Stress score by an estimate of -2.41 (p = 0.047), indicating potential benefits in managing stress alongside traditional therapies.

Key findings

  • The inMind intervention led to a reduction in DASS-Stress by an estimate of -2.41 (p = 0.047).
  • Directionally consistent reductions were observed in depressive and anxiety symptoms.
  • High adherence rates were reported in both groups during the trial.

Why it matters

The findings suggest that digital health interventions like inMind may provide accessible tools for managing stress in patients with MDD, potentially enhancing treatment outcomes when used alongside pharmacotherapy.

What to keep in mind

Significant carry-over effects complicated causal interpretation due to the no-washout design.

Source

Published in J Affect Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

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