Barriers and facilitators to detoxification from opioid substitution treatment: A mixed-methods systematic review.

AddictionJun 17, 2026 (epub)

Amy Bagshaw, Suleyman Shah, India Olchefske et al.

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In 30 seconds

This mixed-methods systematic review examined barriers and facilitators to detoxification from opioid substitution treatment (OST) in individuals with opioid dependence. Out of 1999 studies, 41 were included, revealing that fear, emotional resurgence, and low confidence hinder detoxification, while psychological readiness and supportive relationships facilitate it. The review highlights the complexity of factors influencing detoxification outcomes.

Key findings

  • 54% of included studies were rated high quality, while 37% were medium quality.
  • Barriers to detoxification include fear, emotional resurgence, and low confidence.
  • Facilitators for successful detoxification include psychological readiness and supportive relationships.
  • Factors affecting detoxification were identified at both individual and structural levels.

Why it matters

Understanding the barriers and facilitators to detoxification from OST is crucial for clinicians to support patients in their transition to a drug-free life, ultimately improving treatment outcomes for opioid dependence.

Source

Published in Addiction. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

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