Successful treatment of idiopathic multicentric Castleman disease with TAFRO and kidney involvement: case report and literature review.
Ahmed I Kamal, Hima Doppalapudi, Thien Ho et al.
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Case in brief
A patient with idiopathic multicentric Castleman disease (iMCD-TAFRO) presented with acute kidney failure, characterized by severe renal dysfunction and other systemic symptoms. The case highlights the challenges in diagnosing this rare condition due to overlapping symptoms with other diseases. The patient was treated successfully with the IL-6 antagonist siltuximab, leading to improvement in kidney function and overall health.
Diagnostic / clinical pearl
Clinicians should be aware of the potential for acute kidney injury in patients with iMCD-TAFRO, as early recognition and treatment are critical to improving outcomes.
Why it matters
This case underscores the importance of understanding the renal manifestations of iMCD-TAFRO, which may not be well-documented in existing literature, thereby aiding nephrologists in managing similar cases.