Limb Compression Therapy and Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self-Controlled Study(NEURO-GLOVE Trial).
Kadriye Başkurt, Galip Can Uyar, Enes Yeşilbaş et al.
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In 30 seconds
This prospective, self-controlled study evaluated the effect of dual-site mechanical compression on chemotherapy-induced peripheral neuropathy (CIPN) in 76 women with gynecologic cancers receiving carboplatin-paclitaxel. Results showed that moderate-to-severe CIPN was significantly less frequent in compression limbs compared to control limbs at multiple time points, including Cycle 3 (35.5% vs. 53.9%; p=0.001) and 6 months (20.3% vs. 33.8%; p=0.002).
Key findings
- Moderate-to-severe CIPN was observed less frequently in compression limbs than control limbs at Cycle 3 (35.5% vs. 53.9%; p=0.001).
- At end of treatment, CIPN was 59.2% in compression limbs versus 69.7% in control limbs (p=0.021).
- Sensory CIPN20 scores were lower in compression limbs from end of treatment onward (7.5 vs. 10.2; p<0.001).
- Dual-site mechanical compression was associated with reduced incidence and persistence of CIPN.
Why it matters
Chemotherapy-induced peripheral neuropathy can significantly impact patient quality of life and treatment adherence. This study suggests that a simple, low-cost intervention may help mitigate these effects, potentially improving patient outcomes and treatment tolerability.