Comparative efficacy, recovery, and pigmentary safety of radiofrequency microneedling and fractional carbon dioxide laser for facial atrophic acne scars: a prospective randomized split-face trial.
J Dermatolog TreatJun 18, 2026 (epub)
Clinical ResearchDermatology
Wei Li, Chunjiao Zheng, Xiaohai Yuan et al.
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In 30 seconds
This prospective randomized split-face trial compared the efficacy and safety of radiofrequency microneedling (RFMN) and fractional carbon dioxide laser (FCO2) in 30 patients with facial atrophic acne scars. Both treatments significantly improved ECCA scores, with RFMN showing faster recovery and fewer adverse pigmentary events, making it a potentially safer option.
Key findings
- Mean ECCA scores decreased from 54.73 to 30.53 with RFMN and from 53.67 to 31.03 with FCO2.
- RFMN demonstrated shorter durations of erythema, pain, swelling, and scab detachment.
- Patients reported higher satisfaction with RFMN after the first session and at all follow-ups.
- Fewer post-inflammatory hyperpigmentation events were associated with RFMN.
Why it matters
Understanding the comparative efficacy and safety of these treatments can guide clinicians in selecting appropriate interventions for patients with facial atrophic acne scars, potentially improving patient outcomes and satisfaction.