Oral and Vaginal Probiotics and Pregnancy Outcomes in Women With Infertility: A Systematic Review and Meta-analysis.
Maedeh Moradi, Jessica A Grieger, Yilin Tong et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of oral and vaginal probiotics on pregnancy outcomes in 2,339 women with infertility. The study found that oral probiotics were linked to higher biochemical pregnancy rates (RR 1.27), clinical pregnancy rates (RR 1.71), and live-birth rates (RR 1.24), while vaginal probiotics were associated with a reduced risk of miscarriage (RR 0.57).
Key findings
- Oral probiotics increased biochemical pregnancy rates (RR 1.27, 95% CI 1.01-1.60).
- Oral probiotics improved clinical pregnancy rates (RR 1.71, 95% CI 1.01-2.91).
- Oral probiotics enhanced live-birth rates (RR 1.24, 95% CI 1.01-1.51).
- Vaginal probiotics reduced miscarriage risk (RR 0.57, 95% CI 0.38-0.84).
Why it matters
Understanding the role of probiotics in improving pregnancy outcomes can inform treatment strategies for women facing infertility. This evidence may guide clinicians in recommending probiotic use as part of fertility management.
What to keep in mind
The quality of evidence was low to very low, which may affect the reliability of the findings.