Are psychotropic medications equivalent in fall risk among nursing home residents? A meta-analysis of pharmacologic subtypes and polypharmacy effects.
Int J Nurs StudJun 10, 2026 (epub)
Huizhen Zhang, Wei Li, Shengze Zhi et al.
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In 30 seconds
This meta-analysis examined the fall risk associated with various psychotropic medications in nursing home residents. It included 20 studies and found that typical antipsychotics (OR = 1.66) and atypical antipsychotics (OR = 1.78) significantly increased fall risk, along with other medication classes. No significant difference in fall risk was observed between atypical and typical antipsychotics.
Key findings
- Typical antipsychotics were associated with an odds ratio of 1.66 for fall risk.
- Atypical antipsychotics had an odds ratio of 1.78 for increased fall risk.
- Polypharmacy was linked to an odds ratio of 1.64 for falls.
- Long-acting sedative-hypnotics showed an odds ratio of 1.43 for fall risk.
Why it matters
Understanding the differential fall risk associated with psychotropic medications is crucial for clinicians managing the safety of nursing home residents. This knowledge can guide safer prescribing practices and help mitigate fall-related injuries.