Anti-adenylate kinase 5 encephalitis: Case series and review of 18 F-DPA714 PET/MRI radiographic changes.

J NeuroimmunolJun 15, 2026 (epub)
Case ReportNeurologyPsychiatry

Siyu Dong, Xiaoyu Chen, Chenchen Duan et al.

✦ AI-curated · Sources linked

Case in brief

Two female patients, aged 15 and 65, presented with subacute cognitive decline and psychiatric disturbances. Both were found to have anti-adenylate kinase 5 antibodies and exhibited significant hippocampal atrophy on MRI. 18 F-DPA714 PET/MRI showed increased tracer uptake in multiple brain regions. The younger patient improved significantly after treatment, while the older patient had limited recovery.

Diagnostic / clinical pearl

Anti-adenylate kinase 5 encephalitis can present with prominent cognitive and psychiatric symptoms, and 18 F-DPA714 PET/MRI may be useful in assessing neuroinflammation.

Why it matters

The case highlights the potential role of B-cell immunotherapy in treating anti-AK5 encephalitis, suggesting a need for further research into targeted therapies.

Source

PubMed · PMID 42314508

Published in J Neuroimmunol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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