High mean arterial pressure after reperfusion is associated with unfavorable functional outcome in patients with acute ischemic stroke: A post hoc study of BAST trial.
Clin Neurol NeurosurgJun 15, 2026 (epub)
Changjun Li, Xinyi Li, Xue Tian et al.
✦ AI-curated · Sources linked
In 30 seconds
This post hoc analysis of the BAST trial examined the relationship between mean arterial pressure (MAP) after reperfusion and functional outcomes in 1213 patients with acute ischemic stroke (AIS). Higher MAP levels were linked to a lower likelihood of favorable outcomes at 90 days, with each 10 mmHg increase in MAP associated with a 0.782-fold decrease in the probability of achieving a favorable outcome (P < 0.001).
Key findings
- Higher MAP tertiles were associated with lower rates of favorable functional outcomes at day 90 (P < 0.001).
- Each 10 mmHg increase in MAP resulted in a 0.782-fold decrease in the probability of a favorable outcome (P < 0.001).
- The association of MAP with functional outcomes was consistent across various subgroups, including age and comorbidities.
Why it matters
Understanding the impact of MAP after reperfusion can help clinicians assess prognosis in AIS patients. This knowledge may guide monitoring and management strategies to improve patient outcomes.