Association of serum lactate with outcome after pediatric out-of-hospital cardiac arrest: a secondary analysis of the Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) trial.
Carly D Schmidt, Erin F Carlton, Kent Page et al.
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In 30 seconds
This secondary analysis of the THAPCA trial evaluated the association of serum lactate levels with 12-month neurobehavioral outcomes and hospital mortality in pediatric patients after out-of-hospital cardiac arrest. The study included 213 participants, revealing that higher lactate levels within 6 hours of return of spontaneous circulation were linked to unfavorable outcomes, with a median lactate of 7.8 mmol/L in those with unfavorable outcomes compared to 3.1 mmol/L in those with favorable outcomes.
Key findings
- 82% of participants had a primary unfavorable outcome at 12 months.
- Median lactate was 7.8 mmol/L for unfavorable outcomes versus 3.1 mmol/L for favorable outcomes.
- For each 1 mmol/L increase in lactate, the odds of unfavorable outcome increased by 1.40.
Why it matters
Understanding the relationship between serum lactate levels and outcomes after pediatric cardiac arrest can aid clinicians in early neuroprognostication and mortality risk assessment, potentially guiding treatment decisions.