Impact of Surgical Delay on Breast Cancer Prognosis: Systematic Review and Meta-analysis.
Camille Gervais, Khadija Brouillette, Tarek Benzouak et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of surgical delays on survival in invasive breast cancer, analyzing data from 26 studies with 4,921,120 patients. The study found that delays of 30-59 days, 60-89 days, and 90-120 days from diagnosis to surgery were associated with increased mortality, with a hazard ratio of 1.37 for delays of 90-120 days compared to surgery within 30 days.
Key findings
- Delays of 30-59 days were associated with increased mortality (HR 1.08; p = 0.02).
- Delays of 60-89 days showed a 12% higher risk of mortality (HR 1.12; p < 0.001).
- Delays of 90-120 days were linked to a 37% higher risk of mortality (HR 1.37; p = 0.002).
- Each additional 30-day delay increased mortality risk by 15% (HR 1.15; p < 0.001).
Why it matters
Understanding the relationship between surgical timing and breast cancer outcomes is crucial for optimizing treatment protocols. This evidence highlights the importance of timely surgical intervention to improve survival rates in patients with invasive breast cancer.