The impact of (poly)phenol-rich sugarcane extract intervention on markers of gastrointestinal integrity and systemic inflammation in response to exertional-heat stress.
Ulluwis H A J Hewawansa, Kayla Henningsen, Natália Vilela Silva Daniel et al.
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In 30 seconds
This randomized controlled trial investigated the effects of a (poly)phenol-rich sugarcane extract (PRSE) on gastrointestinal integrity and systemic inflammation during exertional-heat stress (EHS) in 14 participants. The study found that PRSE supplementation resulted in lower pre-EHS plasma I-FABP levels and attenuated the increase in plasma IL-8 compared to placebo, suggesting potential benefits for intestinal health and inflammation management during EHS.
Key findings
- PRSE resulted in lower pre-EHS plasma I-FABP concentration compared to placebo.
- Plasma IL-8 concentration increased over time but was attenuated by PRSE compared to placebo.
- Higher rectal temperature and physiological strain index were observed with PRSE.
- Average symptom severity of exercise-associated gastrointestinal symptoms was lower with PRSE.
Why it matters
Understanding the impact of dietary interventions like PRSE on gastrointestinal integrity and inflammation during heat stress can inform strategies to mitigate exercise-related health risks, particularly in athletes and active individuals exposed to high temperatures.