Diagnostic performance of FAPI PET/CT for the detection of peritoneal metastases: an updated systematic review and bivariate meta-analysis.
Eur J RadiolJun 16, 2026 (epub)
Wan Qi-Chang, Min Kai-Yin, Wang Cheng-Yi et al.
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In 30 seconds
This systematic review and bivariate meta-analysis evaluated the diagnostic accuracy of FAPI PET/CT for detecting peritoneal metastases (PM) in cancer patients. The analysis included 15 studies with 837 patients. The pooled sensitivity for patient-based analysis was 97% (95% CI, 91-99%), and for lesion-based analysis, it was 92% (95% CI, 83-96%).
Key findings
- Pooled sensitivity for patient-based analysis was 97% (95% CI, 91-99%).
- Pooled specificity for patient-based analysis was 95% (95% CI, 80-99%).
- Pooled sensitivity for lesion-based analysis was 92% (95% CI, 83-96%).
- Pooled specificity for lesion-based analysis was 90% (95% CI, 70-97%).
Why it matters
The high sensitivity and specificity of FAPI PET/CT for detecting peritoneal metastases suggest it could be a valuable tool in clinical practice for assessing cancer spread, particularly in high-risk populations.