Impact of early fresh frozen plasma administration on clinical outcomes in snakebite-induced coagulopathy: A systematic review.
Swagatika Pati, Priyanka Priyadarshini Pattanayak, Debjani Priyadarsini Das et al.
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In 30 seconds
This systematic review evaluated the impact of early fresh frozen plasma (FFP) administration alongside antivenom in patients with snakebite-induced coagulopathy. Analyzing five studies, it was found that while FFP improved laboratory recovery of coagulation parameters, it did not significantly reduce mortality or major morbidity. The recovery time for coagulation parameters decreased from approximately 24 hours to 6-12 hours in some trials.
Key findings
- FFP administration reduced recovery time of coagulation parameters from ∼24 hours to 6-12 hours.
- No statistically significant reduction in mortality was observed with FFP addition.
- Clinical outcomes like major bleeding and hospital stay showed variable results.
- Adverse effects from FFP were infrequent, including allergic reactions and one case of TRALI.
Why it matters
Understanding the role of FFP in snakebite management is crucial, especially in resource-limited settings where timely treatment is essential. This review highlights the need for evidence-based guidelines regarding FFP use in conjunction with antivenom.