Variation in sleep and instability in mood in patients with bipolar disorder and the association between these - an exploratory post hoc study on daily smartphone-based data from two separate randomised controlled trials.
Maria Faurholt-Jepsen, Asbjørn Risom, Caroline Fussing Bruun et al.
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In 30 seconds
This exploratory post hoc study analyzed daily smartphone-based data from 370 patients with bipolar disorder to investigate the relationship between sleep variation and mood instability. The results indicated a positive association between sleep variation over the prior three days (1.22, 95% CI: (1.19; 1.24), p < 0.0001) and the prior week (1.40, 95% CI: (1.36, 1.44), p < 0.0001) with mood instability.
Key findings
- Sleep variation over the prior three days was positively associated with mood instability (1.22, 95% CI: (1.19; 1.24), p < 0.0001).
- Sleep variation over the prior week also showed a positive association with mood instability (1.40, 95% CI: (1.36, 1.44), p < 0.0001).
- Increasing sleep up to around eight hours was linked to decreased mood instability, while more sleep led to increased instability.
- The estimated inflection point for optimal sleep was approximately 8.05 hours for the A-bipolar study and 8.24 hours for the SMART-Bipolar study.
Why it matters
Understanding the relationship between sleep patterns and mood instability in bipolar disorder can inform treatment strategies and patient management, emphasizing the importance of circadian regulation in mood disorders.
What to keep in mind
Analyses were exploratory and post hoc, relying on patient-reported data, which may affect the reliability of findings.