Ginkgo biloba versus desmopressin in treatment of children with monosymptomatic nocturnal enuresis: A randomized controlled trial.
J Pediatr UrolJun 9, 2026 (epub)
Mohamed El-Shazly, Ammar Alorabi, Ibrahim E Alahmar et al.
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In 30 seconds
This randomized controlled trial evaluated the efficacy and safety of Ginkgo biloba extract (GBE) versus Desmopressin in 398 children aged 5-14 with monosymptomatic nocturnal enuresis. The combination of GBE and Desmopressin resulted in the greatest improvement in wet nights, with a median of 0 wet nights compared to GBE (6) and Desmopressin (2), p < 0.001.
Key findings
- Combination therapy resulted in a median of 0 wet nights compared to GBE (6) and Desmopressin (2), p < 0.001.
- Full response rates were highest with combination therapy at 88.3%, followed by Desmopressin (46.5%) and GBE (24.8%), p < 0.001.
- Quality-of-life scores improved in all treatment groups, with the best outcomes in the combination group.
Why it matters
The findings suggest that Ginkgo biloba, particularly in combination with Desmopressin, may enhance treatment outcomes for children with nocturnal enuresis, potentially improving their quality of life and sleep patterns.