Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen-A Case Report and Literature Review.
William H Wu, Joanna K M Ng, Joshua J X Li
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Case in brief
A patient with metastatic clear cell sarcoma of soft tissue presented with malignant effusions in sputum, peritoneal fluid, and pericardial fluid. Cytological analysis revealed positive findings, which were crucial for diagnosis. The case highlights the importance of distinguishing clear cell sarcoma from metastatic melanoma and carcinoma due to overlapping cytomorphologic features. Diagnosis was confirmed using immunocytochemistry and molecular pathology techniques.
Diagnostic / clinical pearl
Clinicians should be aware of the cytological similarities between clear cell sarcoma and metastatic melanoma or carcinoma, as this can lead to diagnostic challenges.
Why it matters
Understanding the cytological features and diagnostic techniques for clear cell sarcoma is essential for accurate diagnosis and management, particularly in cases with malignant effusions.