Effects of Different Training Modalities on Circulating Irisin Levels in Overweight and Obesity Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Keyvan Hejazi, Gholam Rasul Mohammad Rahimi, Ayoub Saeidi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of various exercise modalities on circulating irisin levels in overweight and obese adults. The analysis included 50 randomized controlled trials with 1780 participants. Exercise training significantly increased circulating irisin levels (SMD 0.62, 95% CI 0.39-0.85, p < 0.001) compared to passive controls, indicating a positive metabolic response to exercise.
Key findings
- Exercise training significantly increased circulating irisin levels (SMD 0.62, 95% CI 0.39-0.85, p < 0.001).
- Fasting blood glucose levels were significantly reduced (SMD -0.61, 95% CI -0.89 to -0.33, p < 0.001).
- High-density lipoprotein cholesterol levels increased significantly (SMD 0.25, 95% CI 0.03-0.47, p = 0.030).
- Resistance training showed the largest increase in irisin (SMD 0.88, 95% CI 0.44 to 1.33, p = 0.001).
Why it matters
Understanding the impact of exercise on irisin levels and other metabolic markers can help clinicians design effective interventions for managing overweight and obesity, potentially improving metabolic health outcomes in these populations.