Investigating the effects of antidepressants on measures of insulin resistance in major depressive disorder: A systematic review.
Sabrina Wong, Gia Han Le, Yang Jing Zheng et al.
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In 30 seconds
This systematic review evaluated the effects of antidepressants on insulin resistance in individuals with major depressive disorder. It found that certain tricyclic antidepressants negatively impact insulin sensitivity, while SSRIs do not show acute effects. Preliminary evidence suggests that agomelatine and bupropion may improve insulin resistance. The review highlights the need for further research in this area.
Key findings
- Tricyclic antidepressants like nortriptyline and amitriptyline disrupt insulin sensitivity both acutely and long-term.
- SSRIs were not associated with acute changes in insulin sensitivity.
- Agomelatine and bupropion may be metabolically neutral and could improve insulin resistance in diabetes.
- SNRIs do not adversely affect glucose-insulin signaling in the long-term.
Why it matters
Understanding the relationship between antidepressants and insulin resistance is crucial, as it can influence treatment choices for patients with major depressive disorder who are at risk for metabolic issues. This knowledge can help optimize both psychiatric and metabolic health outcomes.