Maturity onset diabetes of the young in pregnancy: management, treatment and neonatal outcomes-a systematic review.
Alessandra Romandini, Michela Vergani, Arianna Pani et al.
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In 30 seconds
This systematic review examined pregnancy management and neonatal outcomes across subtypes of maturity-onset diabetes of the young (MODY), using clinical studies identified through Cochrane, EMBASE and PubMed. It analyzed outcomes from 1408 live births among 1183 pregnant women. The review identified specific pregnancy-management guidance for GCK-MODY and HNF1A-MODY, but found no comparable guidance for rarer subtypes; information on these was drawn from an additional literature review. The authors note that evidence for rarer MODY subtypes remains limited.
Key findings
- The review analyzed data on 1408 live births among 1183 pregnant women with MODY.
- Specific pregnancy-management guidelines were identified for GCK-MODY and HNF1A-MODY.
- The review found no specific guidelines for rarer MODY subtypes; available information was summarized from an additional literature review.
Why it matters
MODY subtypes differ, and pregnancy management may depend on the subtype. This review brings together available evidence on maternal management and neonatal outcomes, while highlighting that guidance is available for only some subtypes. Recognizing the evidence gap is important when interpreting recommendations for pregnancies affected by rarer forms of MODY.
What to keep in mind
The authors cite limited data on rarer MODY subtypes and limitations related to the selected search terms and databases.