Hydrogel-based drug delivery systems for oral mucositis: a systematic review of preclinical models and translational perspectives.
Claudia Carrara Cotomacio, Caio Camargo Calarga, João Pedro Alves Noronha de Abreu et al.
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In 30 seconds
This systematic review evaluated preclinical studies on hydrogel-based drug delivery systems for oral mucositis, a common complication of cancer therapies. Eighteen studies were included, revealing that most formulations reduced lesion severity and improved healing. Multifunctional systems showed broader effects compared to conventional gels, highlighting their potential in treatment.
Key findings
- Most hydrogel formulations reduced lesion severity and improved histological healing.
- Multifunctional systems exhibited broader effects than conventional gels.
- Heterogeneity in study design and outcome reporting was noted across the included studies.
Why it matters
Oral mucositis significantly impacts patient quality of life during cancer treatment. Effective local therapies are limited, making the exploration of hydrogel-based systems crucial for improving patient outcomes.
What to keep in mind
The included studies exhibited heterogeneity in design, outcome reporting, and translational endpoints.