Comparing the diagnostic performance of 19-gauge and 22-gauge needles in endoscopic ultrasound-guided liver biopsy: a systematic review and meta-analysis.
Proc (Bayl Univ Med Cent)Jun 22, 2026 (epub)
Muhammad Ali Butt, Rahul Karna, Sheza Malik et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the diagnostic performance of 19-gauge (G) versus 22-G needles in endoscopic ultrasound-guided liver biopsy (EUS-LB). Analyzing six studies, the 19-G needle demonstrated superior tissue adequacy (odds ratio 7.9) and histological diagnosis (odds ratio 7.25) compared to the 22-G needle, with no significant difference in postprocedural pain.
Key findings
- 19-G needles showed superior tissue adequacy with an odds ratio of 7.9.
- Histological diagnosis was more successful with 19-G needles, odds ratio 7.25.
- Both needle sizes had similar performance in obtaining long intact core preprocessing.
- Postprocedural pain was comparable between the two needle sizes.
Why it matters
Understanding the differences in needle performance can guide clinicians in selecting the appropriate needle size for EUS-LB, potentially improving diagnostic outcomes for patients with liver disease.