Hypersexuality across neurological disorders: A systematic review of aetiologies, clinical manifestations, assessment methods, and management strategies.

In 30 seconds

This systematic review analyzed 394 studies involving 46,516 participants to explore hypersexuality (HY) in neurological disorders. The majority of cases (≈61%) were iatrogenic, primarily linked to dopaminergic therapy in Parkinson's disease. The review highlights the need for improved assessment and management strategies for this under-recognized behavioral complication.

Key findings

• Approximately 61% of hypersexuality cases were iatrogenic, mainly due to dopaminergic therapy in Parkinson's disease.
• About 25% of cases were acquired from focal lesions, traumatic brain injury, or neurodegenerative syndromes.
• Nearly half of the studies relied solely on unstructured notes for assessment.
• Less than 10% of studies formally consulted informants for assessment.

Why it matters

Hypersexuality is a significant behavioral complication in neurological disorders that can impact patient quality of life and caregiver burden. Understanding its aetiology and management is crucial for effective clinical practice.