Supratentorial intraparenchymal schwannoma: Systematic review of the literature with an illustrative case.

J Clin NeurosciJun 22, 2026 (epub)
Case ReportNeurosurgery

Adrian E Jimenez, Helen Ellsworth, Gunnar Hargas et al.

✦ AI-curated · Sources linked

Case in brief

A 23-year-old female presented with a right frontal intraparenchymal schwannoma, which was successfully resected via craniotomy. Postoperative pathology confirmed a WHO grade I schwannoma, with specific immunohistochemical markers and a detected CHD7-VGLL3 fusion. The patient achieved gross total resection and demonstrated a favorable postoperative course.

Diagnostic / clinical pearl

Intraparenchymal schwannomas are rare CNS tumors that can present with seizures; surgical resection may lead to significant seizure-freedom in most patients.

Why it matters

This case highlights the importance of recognizing intraparenchymal schwannomas as a potential cause of seizures and provides valuable postoperative seizure-freedom estimates for this rare tumor type.

Source

PubMed · PMID 42330744

Published in J Clin Neurosci. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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