Effect of a pro-fertility diet combined with omega-3 supplementation on embryo quality in infertile women undergoing IVF: a randomized controlled trial.
Mahnaz Ghadimi Yari, Hatav Ghasemi-Tehrani, Awat Feizi et al.
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In 30 seconds
This randomized, single-blind, parallel trial evaluated a pro-fertility diet (PFD) plus supplements in 180 infertile women aged 18–42 years undergoing IVF in Iran. For 60 days, participants received either the structured diet with omega-3, vitamin D, folate and vitamin B12, or general dietary advice with folic acid. The intervention group had higher fertilization rates than controls (0.81 ± 0.16 versus 0.66 ± 0.24; P < 0.001) and a greater proportion of grade A embryos (45.2% versus 21.7%; P = 0.003).
Key findings
- Fertilization rates were 0.81 ± 0.16 with the intervention and 0.66 ± 0.24 with control advice (P < 0.001).
- Embryo formation rates were 0.79 ± 0.26 versus 0.62 ± 0.30 (P < 0.001), and embryo counts were 3.78 ± 2.34 versus 2.22 ± 1.46 (P < 0.001).
- Grade A embryos accounted for 45.2% in the intervention group and 21.7% in controls (P = 0.003).
Why it matters
Embryological outcomes are relevant to IVF treatment, and this trial suggests that a structured dietary and supplement programme may improve fertilization and embryo measures compared with general dietary advice. The findings concern laboratory outcomes; the abstract does not report whether the intervention improved pregnancy or live-birth outcomes.
What to keep in mind
The trial was single-blind and conducted at one fertility centre in Iran; the abstract reports embryological outcomes but not pregnancy or live-birth outcomes.