Inner speech and the neurobiology of psychosis.

In 30 seconds

This meta-analysis reviewed neuroimaging studies to explore the relationship between inner speech and psychotic symptoms, particularly in individuals with psychosis. It found that these individuals exhibited increased activity in motor-related regions and decreased grey matter in auditory cortices and the anterior cingulate cortex. The findings suggest that psychotic symptoms may arise from hyperactivation in inner speech-related areas.

Key findings

• Increased activity in ventral premotor cortices was observed in psychosis spectrum participants.
• Decreased grey matter was noted in bilateral auditory cortices and anterior cingulate cortex.
• Distinct, inversely coupled audiomotor networks were identified in relation to inner speech processing.
• Psychotic symptoms may stem from insufficient suppression of self-generated auditory input.

Why it matters

Understanding the neurobiological underpinnings of psychotic symptoms can inform treatment approaches and enhance the management of conditions characterized by auditory hallucinations and thought disturbances.