Efficacy and hepatotoxicity of Psoralea corylifolia L.: A meta-analysis and machine learning assessment in postmenopausal osteoporosis.
J EthnopharmacolJun 22, 2026 (epub)
Hongjie Yang, Rui Tang, Yajin Ren et al.
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In 30 seconds
This meta-analysis evaluated the efficacy and hepatotoxicity of Psoralea corylifolia in postmenopausal osteoporosis. It included 23 efficacy studies and 7 toxicity studies, revealing a significant improvement in bone mineral density with a standardized mean difference of 4.32 (p < 0.001). Bayesian modeling suggested a favorable benefit-risk profile for a proposed investigational dose.
Key findings
- P. corylifolia significantly improved bone mineral density with a standardized mean difference of 4.32.
- The analysis included 23 efficacy studies and 7 toxicity studies.
- Bayesian modeling indicated a favorable benefit-risk profile within a restricted dose range.
- An investigational reference dose of 4.5 mg/kg for 7.0 weeks was estimated.
Why it matters
Understanding the efficacy and safety of traditional herbs like Psoralea corylifolia is crucial for clinicians managing postmenopausal osteoporosis, as it may offer alternative therapeutic options while addressing safety concerns.