Collision Tumor of Basal Cell Carcinoma and Primary Extramammary Paget Disease: A Case Report and Literature Review.
Keiko Fukuda, Yasuhiro Mitsui, Kohei Ogawa et al.
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Case in brief
A 75-year-old woman presented with a pigmented nodule on the right labium majus, excised and found to contain nests of basaloid cells consistent with basal cell carcinoma (BCC). Further examination revealed bilateral hypopigmented patches, leading to the excision of an additional lesion that showed pagetoid spread, confirming a collision tumor of BCC and primary extramammary Paget disease (EMPD).
What made this case unusual
The coexistence of basal cell carcinoma and primary extramammary Paget disease in a collision tumor is rarely reported, highlighting the diagnostic complexity in vulvar lesions.
Diagnostic / clinical pearl
Clinicians should be vigilant for the possibility of coexisting primary extramammary Paget disease when evaluating vulvar basal cell carcinoma, as it may be easily overlooked.
Why it matters
This case emphasizes the importance of thorough histopathological evaluation in vulvar lesions to avoid misdiagnosis and ensure appropriate management.