Unmanipulated Haploidentical Stem Cell Transplantation Outcome in a Pediatric Patient With CD27 Deficiency and EBV-Induced Diffuse Large B-Cell Lymphoma With Primary CNS Involvement.
Mohammad Jahanpanah, Maryam Behfar, Saeed Yousefian et al.
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Case in brief
A pediatric patient with CD27 deficiency developed EBV-associated diffuse large B-cell lymphoma with primary CNS involvement and experienced an early relapse. The patient underwent unmanipulated haploidentical stem cell transplantation with post-transplant cyclophosphamide. Successful engraftment and controlled graft-versus-host disease were achieved, and after 40 months, the patient remains free of GVHD, primary immunodeficiency, and lymphoma relapse.
Diagnostic / clinical pearl
Clinicians should consider haploidentical stem cell transplantation as a viable option for patients with CD27 deficiency and EBV-related lymphomas, as it can lead to successful outcomes.
Why it matters
This case underscores the potential for effective treatment strategies in patients with rare primary immunodeficiencies and associated malignancies, expanding therapeutic options in challenging clinical scenarios.