Systematic Review and Pooled Analysis of 1,021 Children With Pancreatic Tumors.
J Surg ResJun 23, 2026 (epub)
Christos D Kakos, Ioannis A Ziogas, Stamatios Kokkinakis et al.
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In 30 seconds
This systematic review analyzed 1,021 children with pancreatic tumors, revealing that solid pseudopapillary neoplasm (SPN) was the most common histology (70.4%). Surgical resection was performed in 93.5% of cases, with a 5-year survival rate of 97.4% for SPNs, while pancreatoblastoma had the worst prognosis at 36.7%.
Key findings
- Solid pseudopapillary neoplasm (SPN) accounted for 70.4% of pediatric pancreatic tumors.
- Surgical resection was achieved in 93.5% of patients, with margin-negative resection in 92.7%.
- The 5-year survival rate was 97.4% for SPNs and 36.7% for pancreatoblastomas.
- Recurrence rates were 4.8% for SPNs and 20.5% for pancreatoblastomas.
Why it matters
Understanding the clinical characteristics and outcomes of pediatric pancreatic tumors is crucial for improving diagnosis and treatment strategies. The high survival rates for SPNs highlight the effectiveness of surgical intervention, while the poor prognosis for pancreatoblastoma underscores the need for ongoing research.