Assessment of in-hospital mortality in patients with upper gastrointestinal bleeding on antithrombotic treatment.
Raúl Fernández-García, Raúl Mendoza-Rodríguez, Francisco Valverde-López et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of antithrombotic therapy on in-hospital mortality in patients with upper gastrointestinal bleeding. Analyzing 17 studies with 18,712 patients, the results indicated that antithrombotic therapy at admission was not linked to increased mortality, showing a protective trend (OR 0.79; 95% CI 0.62-1.01), particularly for antiplatelet agents.
Key findings
- Antithrombotic therapy was not associated with increased in-hospital mortality (OR 0.79; 95% CI 0.62-1.01).
- Antiplatelet agents showed a significant protective effect (OR 0.67; 95% CI 0.47-0.95).
- Anticoagulants did not significantly influence mortality (OR 1.09; 95% CI 0.72-1.64).
- Significantly lower mortality was observed in studies focused on non-variceal bleeding (OR 0.60; 95% CI 0.41-0.87).
Why it matters
Understanding the relationship between antithrombotic therapy and mortality in upper gastrointestinal bleeding is crucial for clinicians. This study suggests that antithrombotic therapy may not worsen outcomes, which can inform treatment decisions in this patient population.