Effect of different liposomal bupivacaine concentrations in ultrasound-guided superior trunk block on postoperative analgesia and mobility: a randomized double-blind controlled trial protocol for shoulder arthroscopy.
Ann MedJun 23, 2026 (epub)
Yu Zhou, Hong-Zhang Ding, Xiao-Qian Li et al.
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In 30 seconds
This randomized double-blind controlled trial will evaluate the effects of different concentrations of liposomal bupivacaine (66 mg, 44 mg, and 33 mg) in ultrasound-guided superior trunk block on postoperative analgesia and mobility in 282 adult patients undergoing elective shoulder arthroscopy. The primary outcomes include rest pain NRS score at 48 hours and cumulative oral morphine consumption within 48 hours post-surgery.
Key findings
- Co-primary outcomes include rest pain NRS score at 48 hours and cumulative oral morphine milligram equivalents within 48 hours post-surgery.
- Secondary outcomes will assess pain scores at 6, 24, and 72 hours, and motor function at multiple time points.
- The study aims to determine the optimal concentration of liposomal bupivacaine for effective analgesia.
Why it matters
Understanding the optimal concentration of liposomal bupivacaine for shoulder surgery can enhance postoperative pain management, potentially improving recovery times and patient satisfaction while minimizing opioid consumption.