Sustained pharmacodynamic effects of S-ketamine on cortical excitability and resting-state brain activity: A randomized, placebo-controlled trial.
Br J Clin PharmacolJun 24, 2026 (epub)
Clinical ResearchPsychiatry
Catherine M K E de Cuba, Annika A de Goede, Joost C van Mechelen et al.
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In 30 seconds
This randomized, placebo-controlled trial examined the pharmacodynamic effects of S-ketamine on cortical excitability and brain activity in 16 healthy participants. The study found that intravenous S-ketamine led to a sustained attenuation of long-interval intracortical inhibition (LICI 50) and changes in brain wave activity lasting up to 7 days post-dose, indicating potential delayed effects relevant to its antidepressant action.
Key findings
- IV S-ketamine caused a sustained attenuation of long-interval intracortical inhibition (LICI 50).
- Acute reductions in alpha, beta, and delta power were observed following IV and high-dose oral S-ketamine.
- Delta power showed sustained increases with a less analyte-specific linear concentration-effect relationship.
Why it matters
Understanding the sustained effects of S-ketamine on brain activity may enhance the development of biomarkers for its delayed antidepressant effects, potentially improving treatment strategies for depression.