Mid-term efficacy of endoscopic posterior nasal nerve neurectomy combined with functional endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps: a multicenter randomized controlled Trial.

In 30 seconds

This multicenter randomized controlled trial evaluated the mid-term efficacy of endoscopic posterior nasal nerve neurectomy (PNN) combined with functional endoscopic sinus surgery (FESS) in 60 patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Results indicated that the PNN + FESS group had significantly greater improvements in Total Nasal Symptom Score (TNSS) and SNOT-22 scores at 12 months compared to the FESS group.

Key findings

• At 12 months, the PNN + FESS group showed significantly greater TNSS improvement at all time points (p < 0.05).
• The SNOT-22 score improvement in the PNN + FESS group was significantly greater at 12 months (p < 0.05).
• Both groups exhibited a decrease in serum IL-4 and IL-5 levels.

Why it matters

The findings suggest that combining PNN with FESS may enhance symptom relief and quality of life for patients with CRSwNP, potentially guiding treatment decisions in this population.