Dissociable roles of frontal electroencephalography markers in depression: Predictive value of frontal alpha asymmetry and responsive changes in beta power following home-based brain stimulation.
Ji Seon Ahn, Woo Jung Kim, Kyungun Jhung et al.
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In 30 seconds
This randomized controlled trial investigated EEG predictors of treatment response to transcranial direct current stimulation (tDCS) in individuals with major depressive disorder. Analyzing data from 108 participants, the study found that greater left-lateralized frontal alpha asymmetry (FAA) at baseline was significantly associated with lower depressive symptoms at week 6 in the active tDCS group. Regression analyses confirmed FAA as a significant predictor of treatment outcome.
Key findings
- Greater left-lateralized FAA at baseline was associated with lower BDI-II scores at week 6 in the 6W-active group.
- No significant FAA-depression association was found in the 3W-active-sham group.
- Higher F3 relative alpha power correlated with greater symptom severity in the 3W-active-sham group.
- FAA was identified as a significant predictor of treatment outcome after adjusting for baseline symptoms.
Why it matters
Understanding EEG predictors of treatment response can enhance personalized approaches to neuromodulation in major depressive disorder, potentially improving patient outcomes and treatment efficacy.