Mapping the association between cognitive disengagement syndrome and internalizing disorders: A systematic scoping review with meta-analysis and meta-regression.

J Affect DisordJun 24, 2026 (epub)
Clinical ResearchPsychiatry

Francesco Maria Boccaccio, Renata Rizzo, Concetta Pirrone et al.

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In 30 seconds

This systematic scoping review and meta-analysis examined the relationship between Cognitive Disengagement Syndrome (CDS) and internalizing disorders across 82 studies. It found that individuals with elevated CDS had significantly higher rates of depression (r = 0.56) and anxiety (r = 0.46), with over one-third meeting clinical thresholds. The study highlights CDS as a distinct construct associated with internalizing disorders.

Key findings

  • Individuals with elevated CDS showed higher rates of depression, with a correlation of r = 0.56.
  • Anxiety was also significantly associated with CDS, with a correlation of r = 0.46.
  • More than one-third of individuals with CDS reached clinical thresholds for depression and anxiety.
  • Longitudinal evidence suggests CDS may be a developmental risk factor for later depression.

Why it matters

Understanding the association between CDS and internalizing disorders is crucial for clinicians, as it may inform assessment and intervention strategies for patients exhibiting symptoms of both conditions.

What to keep in mind

The review noted a lack of longitudinal and multi-informant studies, as well as insufficient exploration of functional outcomes related to CDS and internalizing disorders.

Source

Published in J Affect Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

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