Intermittent fasting strategies for metabolic dysfunction-associated steatotic liver disease: A systematic review and frequentist network meta-analysis of randomized controlled trials.
Husam Abu Suilik, Ahmed Farid Gadelmawla, Mohamed Rifai et al.
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In 30 seconds
This systematic review and network meta-analysis evaluated the effects of various intermittent fasting (IF) strategies on metabolic dysfunction-associated steatotic liver disease (MASLD) in 1149 adults. The study found that time-restricted feeding (TRF) was most effective for reducing hepatic steatosis (MD: -23.32 dB/m), while alternate-day fasting (ADF) significantly improved body weight and insulin resistance. None of the regimens improved liver stiffness.
Key findings
- TRF reduced hepatic steatosis by a mean difference of -23.32 dB/m.
- ADF showed the greatest reductions in body weight, waist circumference, and body fat.
- Both the 5:2 Diet and TRF significantly reduced ALT and AST levels.
- The 5:2 Diet led to a modest reduction in LDL-C.
Why it matters
Understanding the effectiveness of different intermittent fasting strategies can help clinicians tailor dietary interventions for patients with MASLD, potentially improving adherence and outcomes in managing this prevalent liver condition.