[Translated article] Safety of excipients in pediatric medications: impact on child health.
Farm HospJun 24, 2026 (epub)
Clinical ResearchPediatrics
Leonel Silva-Chocoteco, Monserratt Abud-González, Cesar Ricardo Cortez-Álvarez et al.
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In 30 seconds
This systematic review evaluated the safety of excipients in pediatric medications, highlighting their potential toxicity in children. The review identified 54 excipients with documented risks, including hepatic, renal, and neurological toxicity. The findings emphasize the need for improved safety evaluations and age-specific formulations due to children's heightened vulnerability.
Key findings
- Fifty-four excipients with potential toxicity in children were identified and classified into four functional groups.
- Notable adverse effects include hepatic, renal, and neurological toxicity, as well as hypersensitivity reactions.
- A significant limitation is the lack of specific data for the pediatric population.
Why it matters
Understanding the safety of excipients is crucial for pediatric care, as children are more susceptible to adverse effects. This knowledge can guide healthcare professionals in making informed decisions regarding medication formulations.