Effect of icosapent ethyl treatment on colorectal tissue marine ω-3 polyunsaturated fatty acid levels among patients with a history of adenoma: a prospective, single-arm clinical trial.
Am J Clin NutrJun 25, 2026 (epub)
Yufeng Chen, Sunjeong Bae, Kai Wang et al.
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In 30 seconds
This prospective, single-arm clinical trial evaluated the impact of 4 g/d icosapent ethyl (IPE) on marine omega-3 polyunsaturated fatty acid levels in colorectal tissue among 81 patients with a history of adenoma. The study found that total marine ω-3 PUFA increased from 2.10% to 5.21%, indicating a significant incorporation of these fatty acids into colorectal tissue.
Key findings
- Total marine ω-3 PUFA in colorectal tissue increased from 2.10% to 5.21%.
- EPA showed the highest increase with a fold change of 5.88.
- The ratio of marine ω-3 to ω-6 PUFA increased with a fold change of 2.58.
- Cumulative IPE treatment correlated positively with changes in tissue EPA composition (Spearman's ρ = 0.23, P = 0.051).
Why it matters
The findings suggest that IPE may enhance the incorporation of beneficial omega-3 fatty acids into colorectal tissue, potentially offering a protective effect against colorectal cancer in patients with a history of adenoma.