Higher Maternal Body Mass Index Attenuates the Response to High-Dose Vitamin D Supplementation During Pregnancy: A Secondary Analysis of the Randomized Vitamin D Antenatal Asthma Reduction Trial (VDAART).
Catherine Jung, Zheng Lu, Diane E Handy et al.
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In 30 seconds
This secondary analysis of the randomized Vitamin D Antenatal Asthma Reduction Trial (VDAART) examined how maternal body mass index (BMI) affects the biochemical response to high-dose vitamin D supplementation during pregnancy. Among 816 participants, high-dose supplementation increased maternal 25(OH)D by 22.43 nmol/L compared to standard-dose in those with BMI <25 kg/m², but the response was significantly lower in overweight and obese groups, with reductions of 37% and 38%, respectively.
Key findings
- High-dose vitamin D increased 25(OH)D by 22.43 nmol/L in participants with BMI <25 kg/m².
- The treatment effect was reduced by 8.39 nmol/L in overweight participants (BMI 25-29.9 kg/m²).
- In obese participants (BMI ≥30 kg/m²), the treatment effect was reduced by 8.63 nmol/L.
- Each 1 kg/m² increase in BMI was associated with a 0.45 nmol/L reduction in treatment effect.
Why it matters
Understanding the impact of maternal BMI on vitamin D response is crucial for optimizing supplementation strategies during pregnancy. This knowledge can help ensure adequate vitamin D levels, which are important for maternal and fetal health.