Vitamin B12 Deficiency in Sickle Cell Disease: Method-Driven Estimates and Systematic Diagnostic Misclassification.
Eur J HaematolJun 25, 2026 (epub)
Tarimoboere Agbalalah, Adekunle Rowaiye, Frances Iseghohi
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In 30 seconds
This systematic review assessed the prevalence of vitamin B12 deficiency in sickle cell disease (SCD) across 14 observational studies. The findings revealed that diagnostic methods significantly influenced prevalence estimates, which ranged from 0% to 70%. The study highlights the need for improved diagnostic approaches to ensure accurate assessment of B12 status in SCD populations.
Key findings
- Prevalence estimates of vitamin B12 deficiency in SCD varied from 0% to 70%, influenced by diagnostic methods.
- 71% of studies used immunoassays, with over one-third relying solely on circulating B12 levels.
- Multi-marker studies reported prevalence estimates between 6.9% and 53%.
Why it matters
Understanding the true prevalence of vitamin B12 deficiency in SCD is crucial for accurate diagnosis and treatment. Misclassification can lead to inappropriate management strategies, impacting patient outcomes.